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Teresa Borras, PhD, MS

Professor

Department of Ophthalmology

Procedures/Research:
Research in glaucoma and gene transfer therapy.

Website: http://www.med.unc.edu/ophth
Teresa Borras, PhD


Certifications
Molecular Biology - Board Certified  (1977)


Education and Training
Graduate School: MS, University of Madrid, 1966
Doctoral: PhD, University of Madrid, Spain, 1977
Fellowship: National Institutes of Health, Bethesda, Maryland, 1977 - 1982
Area: Laboratory of Central Nervous System Studies
  National Institutes of Health, Bethesda, Maryland, 1982 - 1986
Area: Laboratory of Molecular and Developmental Biology


Foreign Languages Spoken
French, Portuguese, Spanish


Professional Positions
  1. Director of Biology, Cusi Research and Development Center Laboratorios Alcon-Cusi, S.A., Barcelona, Spain, 1991

  2. Expert Scientist, National Eye Institute, National Institutes of Health, 1994

  3. Associate Professor of Ophthalmology and Genetics, Duke University Medical Center, 1995


Honors
  1. Jules and Doris Stein Research to Prevent Blindness Professorship, UNC-CH, 2003

  2. Jules and Doris Stein Research to Prevent Blindness Professorship, UNC-CH, 2002

  3. Jules and Doris Stein Research to Prevent Blindness Professorship, Duke, 2001

  4. Jules and Doris Stein Research to Prevent Blindness Professorship, Duke, 2000


Publications
  1. Altered secration of a TIGR/MYOC mutant lacking the olfactomedin domain.
    Authors: Caballero M, Rowlette LLS, and Borras T
    Biochimica et Biophysica Acta 1502 pp. 447-460, 2000

  2. Genes up-regulated in the human tubecular meshworkin response to elevated intraocular pressure.
    Authors: Gonzalez, P., Epstein, D.L., and Borras, T.
    Investigative Ophthalmology and Visual Science, 2000

  3. Characterization of gene expression in the human trabecular meshwork using single-pass sequencing of 1060 clones.
    Authors: Gonzalez, P., Epstein, D.L., and Borras, T.
    Investigative Ophthalmology and Visual Science 41 pp 3678-3693, 2000

  4. Ineficient processing of an olfactomedin-defective myocilin mutant: potential physiological relevance to glaucoma.
    Authors: Caballero M and Borras T.
    Biochemical and Biophysical Research Communications 282 pp. 662-670, 2001

  5. Non-invasive observation of repeated adenoviral GFP gene delivery to the anterior segment of the monkey in vivo.
    Authors: Borras T, Gabelt BA, Klintworth GK, Peterson JC, and Kaufman PL
    Journal of Gene Med 3 pp. 437-449, 2001

  6. Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments.
    Authors: Borras T, Rowlette, Tamm ER, Gottanka J, and Epstein DL
    Investigative Ophthalmology and Visual Science 43 pp 33-40, 2002

  7. Gene transfer of dominant-negative RhoA increases outflow facility in perfursed anterior segments.
    Authors: Vittitow JL, Garg R, Rowlette LLS, Epstein DL, O'Brien ET, and Borras T.
    Molecular Vision 8 pp 32-44, 2002

  8. Gene therepy of glaucoma: treating a multifaceted, chronic disease.
    Authors: Borras T, Brandt CR, Nickells R, and Ritch R.
    Investigative Ophthalmology and Visual Science 43 pp 2513-2518, 2002

  9. Tissue differential ,icroarray analysis of dexamethasone induction reveals potential mechanisms of steroid glaucoma.
    Authors: Lo WR, Rowlette LLS, Caballero M, Yang P, Hernandez MR and Borras T.
    Investigative Ophthalmology and Visual Science 44 pp. 473-485, 2003

  10. Transcription profiling in Drosphila eyes that overexpress the human Glaucoma-Associated Trabecular Meshwork-Inducible Glucocorticoid Response Protein/Myocilin (TIGR/MYOC)
    Authors: Borras T, Morozova TV, Heinsohn SL, Lyman RF, Mackay FC, and Anholt RRH.
    Genetics 163 pp. 637-645, 2003

  11. Recent developments in ocular gene therepy
    Authors: Borras T.
    Experimental Eye Research 76 pp 1-10, 2003

  12. Gene expression in the trabecular meshwork and the influence of intraocular pressure.
    Authors: Borras T
    Prog Retin Eye Res 22:435-63, 2003


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